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Chemistry Is Everywhere Actual Yields in Drug Synthesis and Purification Many drugs are the product of several steps of chemical synthesis Each step typically occurs with less than 100% yield, so the overall percent yield might be very smallMole ratio MgSiO = 113 !142a Percentage yield of the product of a reaction Even though no atoms are gained or lost in a chemical reaction (law of conservation of mass), unfortunately it is not always possible to obtain the calculated amount of a product (ie 100% yield) because the reaction may not go to completion because it may be reversible or some of the product may be lost when it is separated from the Reaction Yield An Overview Sciencedirect Topics How to calculate yield organic chemistry